Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC020
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-23 11:56
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Requip modutab a 20mg tbl Yumex a 5mg Old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.66 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.66 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 13, 'TP': 24, 'FP': 17}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 4, 'TN': 3, 'TP': 38, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 4
timePerCircleCoV 0.213698
timePerCircleSlope -0.0602424
meanError 1.86391
tremorFreq 6.64062
tremorRelPower 29.4681
tremorGyroAmpMean 0.0154095
tremorGyroAmpSlope 0.0108521
tremorGyroAmpCoV 0.413282
tremorCoordAmpMean 0.131668
tremorCoordAmpSlope -0.0239307
tremorCoordAmpCoV 1.09722
tremorAccAmpMean 0.0206923
tremorAccAmpSlope 0.00980038
tremorAccAmpCoV 0.324299
tremorPcRelVar 0.788502
tremorPcX 0.133579
tremorPcY 0.991038

Circle Segment 1

Duration 5.88 s, Accuracy Estimate 1.563 (lower is better)

Circle Segment 2

Duration 5.12 s, Accuracy Estimate 1.439 (lower is better)

Circle Segment 3

Duration 3.96 s, Accuracy Estimate 1.621 (lower is better)

Circle Segment 4

Duration 3.64 s, Accuracy Estimate 1.729 (lower is better)

Circle Segment 5

Duration 4.04 s, Accuracy Estimate 1.785 (lower is better)

Circle Segment 6

Duration 3.72 s, Accuracy Estimate 1.86 (lower is better)

Circle Segment 7

Duration 3.68 s, Accuracy Estimate 1.835 (lower is better)

Circle Segment 8

Duration 3.44 s, Accuracy Estimate 1.87 (lower is better)

Circle Segment 9

Duration 3.44 s, Accuracy Estimate 1.994 (lower is better)

Circle Segment 10

Duration 3.08 s, Accuracy Estimate 2.942 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 8.58
timePerSpiralCoV 0.192122
timePerSpiralSlope -0.0565374
meanError 2.39982
tremorFreq 5.95703
tremorRelPower 23.3469
tremorGyroAmpMean 0.0275267
tremorGyroAmpSlope 0.00631931
tremorGyroAmpCoV 0.344337
tremorCoordAmpMean 0.0845445
tremorCoordAmpSlope 0.0111613
tremorCoordAmpCoV 0.857292
tremorAccAmpMean 0.0362128
tremorAccAmpSlope 0.0052344
tremorAccAmpCoV 0.336932
tremorPcRelVar 0.767232
tremorPcX 0.488099
tremorPcY 0.872788

Spiral Segment 1

Duration 11.76 s, Accuracy Estimate 1.877 (lower is better)

Spiral Segment 2

Duration 10.72 s, Accuracy Estimate 2.009 (lower is better)

Spiral Segment 3

Duration 9.92 s, Accuracy Estimate 2.062 (lower is better)

Spiral Segment 4

Duration 7.68 s, Accuracy Estimate 2.489 (lower is better)

Spiral Segment 5

Duration 8.68 s, Accuracy Estimate 2.309 (lower is better)

Spiral Segment 6

Duration 7.84 s, Accuracy Estimate 2.625 (lower is better)

Spiral Segment 7

Duration 7.4 s, Accuracy Estimate 2.951 (lower is better)

Spiral Segment 8

Duration 7.36 s, Accuracy Estimate 2.293 (lower is better)

Spiral Segment 9

Duration 7.32 s, Accuracy Estimate 2.582 (lower is better)

Spiral Segment 10

Duration 7.12 s, Accuracy Estimate 2.801 (lower is better)

Elel

eDurationMean 0.288833
eDurationStd 0.0389669
eDurationStdnorm 0.134911
eDurationMedian 0.2825
eDurationQuartdelta 0.05
eDurationQuartdeltanorm 0.176991
eDurationKurt 4.86678
eDurationTrenddiff -0.015
eDurationTrendratio 0.948276
eWidthMean 7.3983
eWidthStd 1.68142
eWidthStdnorm 0.227272
eWidthMedian 7.3125
eWidthQuartdelta 1.755
eWidthQuartdeltanorm 0.24
eWidthKurt 3.5205
eWidthTrenddiff -0.819
eWidthTrendratio 0.890625
eHeightMean 18.1623
eHeightStd 3.8985
eHeightStdnorm 0.214648
eHeightMedian 18.954
eHeightQuartdelta 7.137
eHeightQuartdeltanorm 0.376543
eHeightKurt 1.73136
eHeightTrenddiff 3.744
eHeightTrendratio 1.24242
eAspectMean 0.414537
eAspectStd 0.0814296
eAspectStdnorm 0.196435
eAspectMedian 0.395746
eAspectQuartdelta 0.132887
eAspectQuartdeltanorm 0.33579
eAspectKurt 2.08769
eAspectTrenddiff -0.103785
eAspectTrendratio 0.786011
eSlantMean 0.0177574
eSlantStd 0.130033
eSlantStdnorm 7.32277
eSlantMedian 0.0430566
eSlantQuartdelta 0.162673
eSlantQuartdeltanorm 3.77812
eSlantKurt 3.07053
eSlantTrenddiff -0.046729
eRtopMean 0.776795
eRtopStd 0.0873901
eRtopStdnorm 0.112501
eRtopMedian 0.793052
eRtopQuartdelta 0.107857
eRtopQuartdeltanorm 0.136003
eRtopKurt 2.97448
eRtopTrenddiff 0.0139898
eRbotMean 0.775367
eRbotStd 0.255956
eRbotStdnorm 0.33011
eRbotMedian 0.707826
eRbotQuartdelta 0.348541
eRbotQuartdeltanorm 0.492411
eRbotKurt 2.86097
eRbotTrenddiff 0.0771429
eRrightMean 0.886475
eRrightStd 0.0432409
eRrightStdnorm 0.0487785
eRrightMedian 0.888885
eRrightQuartdelta 0.0726522
eRrightQuartdeltanorm 0.0817341
eRrightKurt 2.10018
eRrightTrenddiff 0.0410686
eRleftMean 0.373527
eRleftStd 0.102248
eRleftStdnorm 0.273737
eRleftMedian 0.355242
eRleftQuartdelta 0.130533
eRleftQuartdeltanorm 0.367449
eRleftKurt 2.99101
eRleftTrenddiff -0.0145802
lDurationMean 0.329583
lDurationStd 0.0265771
lDurationStdnorm 0.0806384
lDurationMedian 0.33
lDurationQuartdelta 0.035
lDurationQuartdeltanorm 0.106061
lDurationKurt 2.3176
lDurationTrenddiff -0.015
lDurationTrendratio 0.955882
lWidthMean 8.04375
lWidthStd 0.877754
lWidthStdnorm 0.109123
lWidthMedian 7.839
lWidthQuartdelta 1.17
lWidthQuartdeltanorm 0.149254
lWidthKurt 3.23562
lWidthTrenddiff -0.5265
lWidthTrendratio 0.935714
lHeightMean 31.8825
lHeightStd 5.19266
lHeightStdnorm 0.162869
lHeightMedian 29.8935
lHeightQuartdelta 9.6525
lHeightQuartdeltanorm 0.322896
lHeightKurt 1.65532
lHeightTrenddiff 1.3455
lHeightTrendratio 1.04582
lAspectMean 0.257715
lAspectStd 0.0442431
lAspectStdnorm 0.171675
lAspectMedian 0.263262
lAspectQuartdelta 0.0631693
lAspectQuartdeltanorm 0.239948
lAspectKurt 2.61335
lAspectTrenddiff -0.00525217
lAspectTrendratio 0.980405
lSlantMean -0.00636377
lSlantStd 0.120776
lSlantStdnorm -18.9787
lSlantMedian 0.0184631
lSlantQuartdelta 0.0849824
lSlantQuartdeltanorm 4.60282
lSlantKurt 8.39997
lSlantTrenddiff 0.00163285
lRtopMean 0.823138
lRtopStd 0.0594318
lRtopStdnorm 0.0722014
lRtopMedian 0.823121
lRtopQuartdelta 0.0993092
lRtopQuartdeltanorm 0.12065
lRtopKurt 2.04444
lRtopTrenddiff -0.00368889
lRbotMean 0.862445
lRbotStd 0.402614
lRbotStdnorm 0.466828
lRbotMedian 0.748545
lRbotQuartdelta 0.273493
lRbotQuartdeltanorm 0.365367
lRbotKurt 8.70952
lRbotTrenddiff -0.00323326
lRrightMean 0.930984
lRrightStd 0.0355344
lRrightStdnorm 0.0381686
lRrightMedian 0.931656
lRrightQuartdelta 0.0597734
lRrightQuartdeltanorm 0.0641582
lRrightKurt 2.13835
lRrightTrenddiff -0.0137524
lRleftMean 0.33491
lRleftStd 0.07652
lRleftStdnorm 0.22848
lRleftMedian 0.343855
lRleftQuartdelta 0.106029
lRleftQuartdeltanorm 0.308353
lRleftKurt 2.44892
lRleftTrenddiff -0.00283661

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

FITTS Short Modified

meanTouchScore 1
sumTouchScores 40
meanMovementTime 0.481282
numTouches 40
undershootPercentage 0
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.999641
sumTouchScores 22.9918
meanMovementTime 0.788636
numTouches 23
undershootPercentage 0
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 9.6
timePerZigzagCoV 0.085645
timePerZigzagSlope -0.0520833
meanError 2.8188
tremorFreq 6.05469
tremorRelPower 27.9676
tremorGyroAmpMean 0.0251928
tremorGyroAmpSlope 0.000561598
tremorGyroAmpCoV 0.22132
tremorCoordAmpMean 0.182493
tremorCoordAmpSlope 0.000953271
tremorCoordAmpCoV 1.32809
tremorAccAmpMean 0.0585229
tremorAccAmpSlope 0.00138302
tremorAccAmpCoV 0.248933
tremorPcRelVar 0.965498
tremorPcX 0.326533
tremorPcY -0.945186

ZigZag Segment 1

Duration 10.36 s, Accuracy Estimate 2.841 (lower is better)

ZigZag Segment 2

Duration 10.44 s, Accuracy Estimate 2.61 (lower is better)

ZigZag Segment 3

Duration 9.52 s, Accuracy Estimate 2.851 (lower is better)

ZigZag Segment 4

Duration 9.2 s, Accuracy Estimate 2.79 (lower is better)

ZigZag Segment 5

Duration 8.48 s, Accuracy Estimate 3.002 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 7.064
timePerZigzagCoV 0.0858389
timePerZigzagSlope -0.0509626
zigzagHeightMean 60.895
zigzagHeightCoV 0.0748098
zigzagHeightSlope 0.0229887
meanError 0.0505712
tremorFreq 5.76172
tremorRelPower 40.2939
tremorGyroAmpMean 0.0405676
tremorGyroAmpSlope 0.0291016
tremorGyroAmpCoV 0.155075
tremorCoordAmpMean 0.363084
tremorCoordAmpSlope 0.034828
tremorCoordAmpCoV 1.20883
tremorAccAmpMean 0.120555
tremorAccAmpSlope 0.0103109
tremorAccAmpCoV 0.104549
tremorPcRelVar 0.982753
tremorPcX 0.321103
tremorPcY 0.947044

ZigZag Offset Segment 1

Duration 7.84 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 2

Duration 7.28 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 3

Duration 7.0 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 4

Duration 7.04 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 5

Duration 6.16 s, Accuracy Estimate 0.068 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.74}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.66}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.757648169603542}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8458115572080398}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5902799076172822}